Oct 28, 1998 · Differential Diagnosis of Hereditary Ataxia. Differential diagnosis of hereditary ataxia includes acquired, non-genetic causes of ataxia, such as alcoholism, vitamin deficiencies, multiple sclerosis, vascular disease, primary or metastatic tumors, or paraneoplastic diseases associated with occult carcinoma of the ovary, breast, or lung.Cited by: 31. For a diagnosis of hereditary ataxia, there must be a neurological examination that shows poorly coordinated gait, often combined with uncoordinated finger/hand movements. Difficulty with speech (dysarthria) and uncontrolled eye movements (nystagmus) may also be present. In addition, non-genetic causes of ataxia must be excluded.
Hereditary ataxias are degenerative disorders that may progress over a number of years. How severe the disability depends on the type of ataxia, the age of onset of symptoms, and other factors. Certain types of hereditary ataxias start in childhood while others start in the adult years. Sporadic ataxias. ataxia, acquired and hereditary: Acquired (non-genetic) ataxia. This type of ataxia usually results from some type of environ-mental factor such as a brain injury, tumor or chemical exposure. For example, head trauma or stroke can cause ataxia. Exposure to high levels of alcohol can lead to ataxia. A brain tumor can cause a person to become.
Sporadic (non-hereditary) ataxia. Olivo-Ponto_Cerebellar Atrophy (OPCA) This is a degenerative disease similar to Parkinson's disease but affects the cerebellum and brain stem (pons and medulla). The name currently used is MSA-C (multi-system atrophy-cerebellar .