Peyer patch, any of the nodules of lymphatic cells that aggregate to form bundles or patches and occur usually only in the lowest portion (ileum) of the small intestine; they are named for the 17th-century Swiss anatomist Hans Conrad Peyer. Peyer patches are round or oval and are located in the mucous membrane lining of the intestine. They can be seen by the naked eye as elongated thickened areas, . The number of Peyer's patches peaks at age 15–25 and then declines during adulthood. In the distal ileum, they are numerous and they form a lymphoid ring. At least 46% of Peyer's patches are concentrated in the distal 25 cm of ileum in humans.MeSH: D010581.
The gut-associated lymphoid tissue (GALT) consists of isolated or aggregated lymphoid follicles forming Peyer's patches (PPs). By their ability to transport luminal antigens and bacteria, PPs can be considered as the immune sensors of the intestine.Cited by: 231. Peyer's patches are more numerous in younger individuals and become less prominent with age.Approximately 30 to 40 patches or bundles occur in an individual's intestine, and they appear as elongated thickened areas lacking the villi that are typical of intestinal membrane.
Aug 31, 2018 · On average, each adult has 30 to 40 Peyer’s patches in the organs of the small intestine. They are mostly in the ileum, with some in the adjoining jejunum and a few extending as far as the duodenum. Research has indicated that number of Peyer’s patches present in the intestines drops off significantly after humans age past their late 20s. Dec 13, 2016 · Special epithelial cells known as microfold cells line the side of the Peyer’s patch facing the intestinal lumen, while the outer side contains many lymphoid cells and lymphatic vessels. The function of Peyer’s patches is to analyze and respond to pathogenic microbes in the ileum.
Ileal and jejunal Peyer's patches in piglets are structurally very similar to those of lambs, and it has been shown that piglet ileal Peyer's patch B cell somatic mutation is dependent upon microbial exposure early in life as well (Butler & Sinkora, 2013). Apr 13, 2018 · Peyer’s patches are located in your small intestine, usually in the ileum area. The ileum is the last portion of your small intestine. In addition to further digesting the food you eat, the ileum also absorbs water and nutrients from food. Most people have between 30 and 40 Peyer’s patches, and younger people tend to have more than older people.Author: Jill Seladi-Schulman, Phd.